CD206, also named macrophage mannose receptor (MMR), is a type I single-chain transmembrane glycoprotein of 175 kDa with a multilectin receptor structure. The Mannose Receptor is thought to play a key role in the internalization of sugar-containing proteins thus concentrating antigens for transport to processing compartments and peptide loading compartments. First detected on tissue macrophages, the Mannose Receptor is mainly expressed on immature dendritic cells and on a variety of other cells. Absent on lymphocytes and monocytes, the Mannose Receptor is up-regulated on monocytes during their differentiation to macrophages.